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Chemistry 421 - Organic Chemistry Part 2

Course Topics

The topics for this course are typically allocated as follows (approximate number of lecture and lab hours spent on each topic are shown in the left columns):

Lec
Lab
Topic
5
12
Structure and stability of dienes, molecular orbital description of conjugated systems, reactions of dienes, pericyclic reactions, theory and use of ultraviolet spectroscopy
3
0
Structure and properties of benzene, aromatic, antiaromatic, and nonaromatic compounds, applications of Huckel's Rule, aromaticity of ions and heterocyclic compounds, spectroscopy and nomenclature of aromatic compounds
4.5
12
Reactions of benzene: halogenation, nitration, sulfonation, and Friedel-Crafts, activating and deactivating substituents and directing effects, nucleophilic aromatic substitution and side-chain reactions of benzene derivatives.
3
0
Ethers: structure, nomenclature, physical properties, spectroscopy, synthesis, and reactions.
0
9
Column chromatography: solvent selection, column preparation and use, analysis of product separation.
3
12
Ketones and Aldehydes: structure, nomenclature, physical properties, spectroscopy, synthesis, and reactions.
3
0
Mass Spectrometry: theory and application of mass spectroscopy and the study of the typical mass spectra of common organic functional groups.
3
12
Amines: structure, nomenclature, physical properties, basicity, spectroscopy, synthesis, and reactions, synthesis and reactions of aryl amines.
3
3
Carboxylic acids: structure, nomenclature, physical properties, acidity, spectroscopy, synthesis, and reactions.
4.5
15
Carboxylic acid derivatives: structure, nomenclature, physical properties, spectroscopy, synthesis, and reactions of acid halides, anhydrides, esters, amides, and nitriles.
3
8
Alpha Substitutions of Carbonyl compounds: enols and enolate ions, alpha halogenation, alkylation of enolates and enamines.
6
12
Condensation Reactions: Synthesis and mechanism involving the aldol condensation, crossed aldol, aldol cyclization, Claisen Condensation, crossed Claisen, Dieckmann condensation, malonic ester synthesis, acetoacetic ester synthesis, Michael reaction, Robinson Annulation.
2
0
Carbon-13 NMR Spectroscopy: theory and application.
3
0
Carbohydrates: classification and structure, epimers, cyclic structures, mutarotation, reactions of monosaccharides, reducing and non-reducing sugars, osazones, ether and ester formation, disaccharides and polysaccharides.
2
4
Lipids: introduction to the different classes of lipids, including waxes, triglycerides, phospholipids, steroids, prostaglandins, and terpenes.
4
3
Amino Acids, Peptides, and Proteins: structure and stereochemistry of the alpha-amino acids, acid-base properties, isoelectric points, synthesis of amino acids, structure and nomenclature of peptides, peptide structure determination, solution and solid phase peptide synthesis, protein structure.
0
6
Lab Practical and laboratory final exam
2
0
Final exam

 

Learning Outcomes and Objectives

Upon completion of this course, the student will be able to: